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Chuck Reynolds
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Chuck Reynolds   My Press Releases

What does moderate champagne wine consumption do.?

Published on 3/19/2019
For additional information  Click Here

Phenolic acid intake, delivered via moderate champagne wine consumption, improves spatial working memory via the modulation of hippocampal and cortical protein expression/activation.

                                              

AIMS:

While much data exist for the effects of flavonoid-rich foods on spatial memory in rodents, there are no such data for foods/beverages predominantly containing hydroxycinnamates and phenolic acids. To address this, we investigated the effects of moderate Champagne wine intake, which is rich in these components, on spatial memory and related mechanisms relative to the alcohol- and energy-matched controls.

RESULTS:

In contrast to the isocaloric and alcohol-matched controls, supplementation with Champagne wine (1.78 ml/kg BW, alcohol 12.5% vol.) for 6 weeks led to an improvement in spatial working memory in aged rodents. Targeted protein arrays indicated that these behavioral effects were paralleled by the differential expression of a number of hippocampal and cortical proteins (relative to the isocaloric control group), including those involved in signal transduction, neuroplasticity, apoptosis, and cell cycle regulation. Western immunoblotting confirmed the differential modulation of brain-derived neurotrophic factor, cAMP response-element-binding protein (CREB), p38, dystrophin, 2',3'-cyclic-nucleotide 3'-phosphodiesterase, mammalian target of rapamycin (mTOR), and Bcl-xL in response to Champagne supplementation compared to the control drink, and the modulation of mTOR, Bcl-xL, and CREB in response to alcohol supplementation.

INNOVATION:

Our data suggest that smaller phenolics such as gallic acid, protocatechuic acid, tyrosol, caftaric acid, and caffeic acid, in addition to flavonoids, are capable of exerting improvements in spatial memory via the modulation in hippocampal signaling and protein expression.

CONCLUSION:

Changes in spatial working memory induced by the Champagne supplementation are linked to the effects of absorbed phenolics on cytoskeletal proteins, neurotrophin expression, and the effects of alcohol on the regulation of apoptotic events in the hippocampus and cortex.

Article Produced By
Molecular Nutrition Group, Centre for Integrative Neuroscience and Neurodynamics, School of Chemistry, Food and Pharmacy, University of Reading.

https://www.ncbi.nlm.nih.gov/pubmed/23458470/

Posted by
Chuck Reynolds

The reasoning for this article is to supply information about this wonderful product and also for me to find at least two or more people for this simply amazing opportunity.. You just need to follow the 4 simple steps.. (Join,Train,sigup 2 or more people and then you duplicate. It's that simple..) and it can make you money in the thousands with this business or just be a customer for a very satisfying experience.

There is a video (4 of them, very short (total less then 5 min)) that explains how simple this business works. Check them out then if so inclined, click on my name above and sign up either as a Customer or Distributor.

Thank You
and
Enjoy
Chuck
chuck@dreams-inn.com

 

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