Join me @ IBOtoolbox for free.
Chuck Reynolds
Member Since: 12/6/2012
  
performance / stats
Country: United States
Likes Received: 1666
Featured Member: 0 times
Associates: 2323
Wall Posts: 1989
Comments Made: 1493
Press Releases: 1961
Videos: 1
Phone: 559-369-7791
Skype:     chuck212
profile visitor stats
TODAY: 144
THIS MONTH: 2337
TOTAL: 386611
are we ibo associates?
recent videos
active associates
George Galvin     
Last logged on: 6/16/2019


Ken VanNortwick  
Last logged on: 6/16/2019


Mel Noel    
Last logged on: 6/16/2019


Evelyn Burns    
Last logged on: 6/16/2019


Rachid Raoui    
Last logged on: 6/16/2019


Daniel Rodgers    
Last logged on: 6/16/2019


Katarina Hofbaur  
Last logged on: 6/16/2019


Dennis Thorgesen    
Last logged on: 6/16/2019


Susan Ross    
Last logged on: 6/16/2019


Curtiss Martin    
Last logged on: 6/16/2019


michael shuttlesworth     
Last logged on: 6/16/2019


Iphota themaque    
Last logged on: 6/16/2019


Reinhard Raidl    
Last logged on: 6/16/2019


Matt Bruns     
Last logged on: 6/16/2019


Mary A Gregory      
Last logged on: 6/16/2019


other ibo platforms











Chuck Reynolds   My Press Releases

Resveratrol modulates drug- and carcinogen-metabolizing enzymes

Published on 5/10/2019
For additional information  Click Here

Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer tudy.

             

Resveratrol has been shown to exhibit cancer-preventive activities

in preclinical studies. We conducted a clinical study to determine the effect of pharmacologic doses of resveratrol on drug- and carcinogen-metabolizing enzymes. Forty-two healthy volunteers underwent baseline assessment of cytochrome P450 (CYP) and phase II detoxification enzymes. CYP1A2, CYP2D6, CYP2C9, and CYP3A4 enzyme activities were measured by the metabolism of caffeine, dextromethorphan, losartan, and buspirone, respectively.

Blood lymphocyte glutathione S-transferase (GST) activity and GST-pi level and serum total and direct bilirubin, a surrogate for UDP-glucuronosyl transferase (UGT) 1A1 activity, were measured to assess phase II enzymes. After the baseline evaluation, study participants took 1 g of resveratrol once daily for 4 weeks. Enzyme assessment was repeated upon intervention completion. Resveratrol intervention was found to inhibit the phenotypic indices of CYP3A4, CYP2D6, and CYP2C9 and to induce the phenotypic index of 1A2.

Overall, GST and UGT1A1 activities were minimally affected by the intervention, although an induction of GST-pi level and UGT1A1 activity was observed in individuals with low baseline enzyme level/activity. We conclude that resveratrol can modulate enzyme systems involved in carcinogen activation and detoxification, which may be one mechanism by which resveratrol inhibits carcinogenesis.

However, pharmacologic doses of resveratrol could potentially lead to increased adverse drug reactions or altered drug efficacy due to inhibition or induction of certain CYPs. Further clinical development of resveratrol for cancer prevention should consider evaluation of lower doses of resveratrol to minimize adverse metabolic drug interactions.

Article Produced By

Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA.

https://www.ncbi.nlm.nih.gov/pubmed/20716633

Posted by
Chuck Reynolds

The reasoning for this article is to supply you information about this wonderful product and also for me to find at least two or more people for this simply Amazing Opportunity.. You just need to follow the 4 simple steps..  (Join,Train,sigup 2 or more people and then you duplicate. It's that simple..). This business can make you money in the thousands or just be a customer for a very satisfying experience.

View this video as it helps you to understand a very simple Business Plan. Check it out, then
View these videos (4 of them, very short (total less then 5 min)) that explains how simple
this business works and if so inclined, click on my name above, call me or just sign up
either as a Customer or Distributor.

Thank You
and
Enjoy
Chuck
559-369-7791
chuck@dreams-inn.com
https://chuck212.amazingrape.com/

Member Note: To comment on this PR, simply click reply on the owners main post below.
-  Copyright 2016 IBOsocial  -            Part of the IBOtoolbox family of sites.