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Chuck Reynolds
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Chuck Reynolds   My Press Releases

How is the Bioavailability of resveratrol.

Published on 5/11/2019
For additional information  Click Here

Bioavailability of resveratrol.

                                

This paper reviews our current understanding of the absorption, bioavailability,

and metabolism of resveratrol, with an emphasis on humans. The oral absorption of resveratrol in humans is about 75% and is thought to occur mainly by transepithelial diffusion. Extensive metabolism in the intestine and liver results in an oral bioavailability considerably less than 1%. Dose escalation and repeated dose administration of resveratrol does not appear to alter this significantly.

Metabolic studies, both in plasma and in urine, have revealed major metabolites to be glucuronides and sulfates of resveratrol. However, reduced dihydroresveratrol conjugates, in addition to highly polar unknown products, may account for as much as 50% of an oral resveratrol dose. Although major sites of metabolism include the intestine and liver (as expected), colonic bacterial metabolism may be more important than previously thought.

Deconjugation enzymes such as β-glucuronidase and sulfatase, as well as specific tissue accumulation of resveratrol, may enhance resveratrol efficacy at target sites. Resveratrol analogs, such as methylated derivatives with improved bioavailability, may be important in future research.

Article Produced By

Department of Pharmacology, Medical University of South Carolina, Charleston, 29425, USA.

https://www.ncbi.nlm.nih.gov/pubmed/21261636

Posted by
Chuck Reynolds

The reasoning for this article is to supply you information about this wonderful product and also for me to find at least two or more people for this simply Amazing Opportunity.. You just need to follow the 4 simple steps..  (Join,Train,sigup 2 or more people and then you duplicate. It's that simple..). This business can make you money in the thousands or just be a customer for a very satisfying experience.

View this video as it helps you to understand a very simple Business Plan. Check it out, then
View these videos (4 of them, very short (total less then 5 min)) that explains how simple
this business works and if so inclined, click on my name above, call me or just sign up
either as a Customer or Distributor.

Thank You
and
Enjoy
Chuck
559-369-7791
chuck@dreams-inn.com
https://chuck212.amazingrape.com/

Member Note: To comment on this PR, simply click reply on the owners main post below.
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