Join me @ IBOtoolbox for free.
Chuck Reynolds
Member Since: 12/6/2012
  
performance / stats
Country: United States
Likes Received: 1684
Featured Member: 0 times
Associates: 2326
Wall Posts: 2018
Comments Made: 1502
Press Releases: 1990
Videos: 1
Phone: 559-369-7791
Skype:     chuck212
profile visitor stats
TODAY: 91
THIS MONTH: 2213
TOTAL: 391069
are we ibo associates?
recent videos
active associates
Katarina Hofbaur  
Last logged on: 7/15/2019


John Kespert    
Last logged on: 7/15/2019


Ricky Hinton    
Last logged on: 7/15/2019


Bruno Duarte    
Last logged on: 7/15/2019


Karen Yeung    
Last logged on: 7/15/2019


Antonio Savannah    
Last logged on: 7/15/2019


Everett Walker     
Last logged on: 7/15/2019


Dee Tee    
Last logged on: 7/15/2019


Marty Cooper    
Last logged on: 7/15/2019


Gloria S  
Last logged on: 7/15/2019


Jean Fountain    
Last logged on: 7/15/2019


Sumaya Kabbara El Ayoubi    
Last logged on: 7/15/2019


Rix Robinson    
Last logged on: 7/15/2019


victor chukwuemeka    
Last logged on: 7/15/2019


Erika Libby  
Last logged on: 7/15/2019


other ibo platforms











Chuck Reynolds   My Press Releases

What does Resveratrol induce.? P-9, P-4

Published on 6/21/2019
For additional information  Click Here

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition P-9

Discussion-P-4

Liu et al. showed that resveratrol suppresses mTOR activity by enhancing the affinity between mTOR and DEPTOR, a negative regulator of mTOR. However, we observed no changes in the level of mTOR-interacting DEPTOR (supplementary Fig. S2). This discrepancy may be explained by the differences in experimental conditions. They used a pull-down assay of endogenous mTOR from C2C12, while we immunoprecipitated FLAG-mTOR from HEK293 cells. Additionally, active mTOR was reported to promote the degradation of DEPTOR. Thus, the increase in DEPTOR affinity may be due to the increased level of total DEPTOR proteins within cells due to resveratrol. Altogether, our study suggests that mTOR is a high-affinity direct target of resveratrol.

Resveratrol induces autophagy in various cell lines and in model organisms, such as Caenorhabditis elegans and mice5,6,7. In these reports, authors showed that autophagy induction is necessary for cancer cell death and alleviation of inflammation, and it may even extend the lifespan. Some studies showed decreased mTOR activity along with autophagy induction with resveratrol treatment, but there is no direct evidence suggesting that mTOR is a mediator of autophagy induction by resveratrol. In this study, using a combinatory chemical treatment and ULK1 knockdown, we clearly demonstrated that the mTOR-ULK1 pathway is necessary for autophagy induction by resveratrol.

In addition to resveratrol, other natural polyphenols, including quercetin and rottlerin also induce autophagy, possibly through mTOR. Further studies are necessary to examine the involvement of mTOR in autophagy induction by other natural polyphenols. Inhibition of mTOR has been shown to be a good strategy in the treatment of various illnesses, such as cancer, neurodegenerative diseases, and diabetes. This study will provide a basis for the identification of unknown mTOR-based effects of resveratrol.

Article Produced By

Department of Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea
School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 689-798, Republic of Korea
Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong, Kwangjin-Ku, Seoul 143-747, Republic of Korea

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763238/

(All these Articles can be read with this URL: 
 
https://markethive.com/group/ama/blog/the-role-of-resveratrol-in-achieving-optimal-health-p5 )

Posted by
Chuck Reynolds

The reasoning for this article is to supply you information about this wonderful product and also for me to find at least two or more people for this simply Amazing Opportunity.. You just need to follow the 4 simple steps..  (Join,Train,sigup 2 or more people and then you duplicate. It's that simple..). This business can make you money in the thousands or just be a customer for a very satisfying experience.

View this video as it helps you to understand a very simple Business Plan. Check it out, then
View these videos (4 of them, very short (total less then 5 min)) that explains how simple
this business works and if so inclined, click on my name above, call me or just sign up
either as a Customer or Distributor.

Thank You
and
Enjoy
Chuck
559-369-7791
chuck@dreams-inn.com
https://chuck212.amazingrape.com/

Member Note: To comment on this PR, simply click reply on the owners main post below.
-  Copyright 2016 IBOsocial  -            Part of the IBOtoolbox family of sites.