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posted on:
9/5/2011 8:21:23 PM EST
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Alzheimer and Glutathione
Alzheimer Solution
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Alzheimers Glutathione
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The Alzheimers glutathione connection holds promise for a treatment that could truly help.
There are numerous research papers and studies on the causes of Alzheimers. Science does not fully understand the causes of Azheimers disease. There is growing evidence that life time exposures to toxins, diet, genes, and oxidative stress are all suspects. If fact, they may be co-conspirators in this greatest of all thievery, the stealing of our memories.
The national institute of aging has funded research to help better understand the genetic aspect of Alzheimers.
Low CG Syndrome
One of the main concerns of the disease is oxidative stress. Since glutathione helps fight oxidative stress, it is natural to find it depleted in conditions where there is such oxidation.
Cataracts, Parkinsons disease, glaucoma, and Alzheimers disease are all associated with what is becoming known as Low CG syndrome.
Numerous chronic diseases are associated with a low levels of glutathione. There are currently 68 that can be found in studies. The reality is there may be many more.
•immune disorders
•HIV
•cancers
Glutathione deficiencies are also a part of toxicity as occurs with medication overdose, decreased liver function, eating disorders and malnutrition.
Changes in Intracellular Calcium and Glutathione in Astrocytes as the Primary Mechanism of Amyloid Neurotoxicity
Neuronal (nerve) death was associated with ...glutathione depletion in both astrocytes and neurons. Thus, astrocytes appear to be the primary target of {beta} A, whereas the neurotoxicity reflects the neuronal dependence on astrocytes for antioxidant support.
On Free Radicals
The article is mostly about a genetic component. However it is interesting to note the comments it included.
The article mentioned how several factors are part of the development of Alzheimer's disease (AD), including free radicals. When they are out of balance neuronal death results.
It also pointed to the benefit of glutathione in protection against the disease.
Neuromolecular Med. 2007;9(3):264-9.
Looked at the effects of dietary supplementation with N-acetyl cysteine (with other supplements) on cognitive performance and aggression in both normal mice and mice expressing human ApoE4.
The study suggested that cognitive impairment, behavioral changes like aggressive behavior, depression, and psychosis are due to imbalances.
So it is possible to stop the nerve death by taking supplements that could bring the brain back into balance.
The study demonstrated that administration of N-acetyl cysteine, acetyl-L-carnitine, and S-adenosylmethionine either maintained or even enhanced brain function.
Further, it prevented aggression in the lab mice.
Just to make sure, they stopped the supplementation. The mice got worse. Then back on it again, the mice got better.
Treatment with this combination shows that it is a therapeutic approach that uses a combination of nerve protecting agents.
This is not a human trial. There are many differences between mice, rats and humans. However, it is another indicator that glutathione boosting precursors and SAM-e along with acetyl-L-carnitine can produce beneficial effects.
J Nutr. 2004 Mar;134(3):489-92
The Genetic Implication
This article has an interesting implication regarding the genes.
It said," Glutathione plays important roles in antioxidant defense, nutrient metabolism, and regulation of cellular events (including gene expression, DNA and protein synthesis, cell proliferation and apoptosis, signal transduction, cytokine production and immune response, and protein glutathionylation).
Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the pathogenesis of many diseases (including kwashiorkor, seizure, Alzheimer's disease, Parkinson's disease, liver disease, cystic fibrosis, sickle cell anemia, HIV, AIDS, cancer, heart attack, stroke, and diabetes)."
The Alzheimers and glutathione connection is hopefully a silver lining in a dark cloud.
This is only the beginning of the information on Alzheimers glutathione.
Alzheimers Disease
Alzheimers Disease History
Alzheimers Glutathione Relationship
Alzheimers Early Symptoms
More to come on the Alzheimers glutathione connection.
GlutathioneDiseaseCure.com: The Alzheimers Glutathione Connection Resource
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