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Cynthia Trethewey
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What is the Role of the Endocannabinoid System in the Human Body? CBD Oil & Sleep

Published on 11/2/2017
For additional information  Click Here

By Cindy Trethewey


To learn more about cannabis and improved sleep we need to explore our built-in "endocannabinoid system" that contributes to the regulation of sleep.

What is the Endocannabinoid System, ECS?

According to here is the definition of the ECS:

"The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain) and peripheral nervous system.... CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), Anandamide, as well as its mimetic phytocannabinoid, THC......The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. " See full article here:


Here is a list of psychological and cognitive processes that are initiated and controlled by the ECS in mammals:

  • Fertility
  • Pregnancy
  • Appetite
  • Mood modulation ( euphoria & calm)
  • Pain Sensation
  • Memory
  • Repairing tissues
  • Regulates sleep

Chemicals are produced by the human body called endocannabinoids that are similar in chemical composition to phytocannabinoids found in the cannabis plant. One such endocannabinoid known as the euphoria chemical is called anandamide which is manufactured by the body in quantity during exercise. This euphoria felt during the spread of "anandamide" in the brain happens as the chemical transits across the blood-brain barrier and this feeling of bliss follows, otherwise known as the "runner's high." The phytocannabinoid THC is known to mimic this endocannabinoid, anandamide.

Another endocannabinoid called 2-AG, "arachidonoylglycerol" is active in both CB1 and CB2 receptors is mimicked by CBD. the phytocannabinoid in cannabis called " cannabidiol."

2-AG and CBD are responsible for regulating:

  • Pain management
  • Immune system functions
  • Appetite mechanisms


Pictured above shows a diagram of the receptors in the brain where both CB1 receptors and CB2 receptors send chemical compounds such as 2-AG and anandamide throughout the nervous system and the brain to regulate these bodily functions mentioned above.


"World's Most Misunderstood Plant with SUPER HEALING POWERS" By Dr. Raphael Mechoulem, there are seven tips for a healthy cannabinoid system. If you have time to click on the video that would explain the Endocannabinoid System of the body and how cannabis plays a role in keeping that ECS running smoothly.

1. Exercise.
2. Consume less alcohol.
3. Ingest daily or most days of the week, potent hemp oil with full spectrum terpenes, flavonoids, waxes, cannabinoids like CBD, CBG & other phytonutrients that directly and indirectly affect the Endocannabinoid System.
4. Regularly ingest plants containing cannabinoids and cannabinoids like compounds such as echinacea, black pepper, cacao, and hemp seeds.
5. Engage in stress deducing activity: meditation, listening to binaural beats (alpha wave inducing sounds and beats).
6. Increase Omega 3 fatty acid consumption: It has been linked to upregulation of CB1 and CB2 receptors as well as increased levels of endocannabinoid system enzymes. Foods high in Omega 3 fatty acids are hemp seed, hemp oil, flax seed, chia seed, fish and eggs.
7.  Decrease unhealthy negative dietary habits. Increase healthy food intakes, such as high omega 3 foods, fresh fruits, and vegetables to bring back vital phytonutrients into the cells.
Here is a breakdown of what CBD and THC do:
  • CBD (cannabidiol) induces an alert state in the brain. Larger doses are known to do the opposite and induce drowsiness. Anecdotal evidence revealed in a sleep study showed the administration of 160 mg of CBD decreased nighttime sleep interruptions and resulted in longer sleep duration. This study suggests that higher doses of CBD therapy can benefit insomnia patients with higher quality or sleep and longer episodes of sleep.
  • CBD is considered safe especially when compared to pharmaceutical drugs used to combat insomnia.
  • CBD has shown potential effects with people who have REM behavior disorder (RBD), a disorder that is recognized by the patient delivering intense and violent behavior during their vivid REM dream state.
  • THC (delta 9-tetrahydrocannabinol) brings about a sedative state in the brain. Research involving animal models with OSA or Obstructive sleep apnea, of this condition has shown that THC and the endocannabinoid oleamide together are effective in reducing sleep apnea events.  (Babson 2017 - Babson, Kimberly A., and James Sottile, Danielle Morabito. 2017. “Cannabis, Cannabinoids, and Sleep: Review of the Literature.” Current Psychiatry Report.?)
Sleep, Joint and Muscle Inflammation, and CBD:

In the scientific expose, “Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex®, a Cannabis-Based Medicine,” Russo et al did a synopsis of 13 studies that examined varying cannabis preparations for pain and sleep. In phase II of the study MS patients were dosed with patented formulas of CBD and THC preparations:
  • Tetranabinex (a high THC product); the THC predominant extract significantly improved pain, muscle spasm, spasticity, and appetite.
  • Nabindolex (high CBD) -the CBD predominant extract yielded significant improvement in pain.
  • Sativex® (an almost a 1:1 THC: CBD sublingual remedy) - significantly improved muscle spasm and sleep. [1] [2] [3]

PTSD, Sleep and Cannabis:

PTSD or Post Traumatic Stress Disorder and cannabis treatment have been tested in clinical trials on patients. A small open clinical trial performed in Israel showed anecdotal evidence that 5 mg of smoked THC twice a day resulted in:
  • Improved sleep
  • Reduced frequency of nightmares  (Mechoulam, 2015) 

2016 case study provided validation in the clinical data, the use of CBD-rich oil as a safe and effective treatment for
  • Reducing anxiety 
  • Improving sleep in a young girl with PTSD

CBD-rich strains are becoming more mainstream popular for patients looking for a natural, safe, and organic answer to PTSD, sleep disorders, anxiety, and pain.

Terpenes in the Cannabis plant also can contribute to the effect of sleep-inducing attributes in cannabis. Here is a list of the sleep-inducing sedative terpenes in cannabis:
  • Terpinolene
  • Nerolidol 
  • Phytol
  • Linalool
  • Myrcene
While some people are turning to cannabis to solve their sleep disorders, even more, are still continuing to rely on pharmaceutical hypnotic sleeping pills, such as:
  • Zolpidem (Ambien, Edlmar, Intermezzo, and Zolpimist) 
  • Temazepam (Restoril)
  • Eszopiclone (Lunesta) 
  • Zaleplon (Sonata)
  • Triazolam (Halcion) 
  • Flurazepam (Dalmane and Dalmadorm)
  • Quazepam
  • Other barbiturates used for sleep.
39 out of 40 studies, found that consumption of hypnotics is “associated with excess mortality” 4.6 times greater risk of death for hypnotic over non-users of hypnotics. [4]

This article does not suggest that you should run out and buy THC-rich cannabis, especially if you live in a state where THC medicines cannot be recommended by doctors or where recreational THC products are not sold. 



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  • Energizing your body
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  • Improved focus
  • Support and more restful and relaxing sleep
  • Antioxidize and neutralize free radicals
  • Promote healthier skin and nails
  • Promote a healthier immune system
  • Aids joint, bone & muscle health
  • Promote anti-inflammatory qualities to ease aches and discomfort
  • Promote improved metabolism, weight loss, and fat burning when combined with diet and exercise
  • Broad-spectrum endo-cannabinoid system balance & support.
  • 28 added plant-based terpenes & phytocannabinoids CBD, CBDa, CBC, CBG and CBN encourage body and brain balancing functions



If you enjoyed this article and would like to try Evolv Entourage2 CBD hemp oil CLICK HERE







*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Any medical references or articles cited are for educational purposes only.

Safety Information:

  • Keep out of reach of children.
  • This product is not meant for individuals with a history of heart conditions.
  • Do not take if pregnant or nursing.
  • Consult your physician before starting a new dietary supplement.
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