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Gene Hughes (MD)
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Gene Hughes (MD)   My Press Releases

Your Endocannabinoid System

Published on 12/14/2018
For additional information  Click Here


The journey to the discovery of the endocannabinoid system actually started in 1895 when researchers Wood, Sivey and Easterfield were able to isolate and identify the very first plant-derived cannabinoid, cannabinol (CBN)

In the early and mid-90s, Mechoulam and colleagues located and identified two of the body’s naturally produced major endocannabinoids, anandamide and 2-arachidonoylglycerol.

Discovering the presence of an endocannabinoid system, which regulates homeostasis in the human body, opened the door for greater breakthroughs on the therapeutic application potential of cannabinoids.

Scientists are still learning more about the role that the endocannabinoid system plays in our health, and more research is still being done. They have established that the system, when working properly, helps regulate processes like sleep, appetite, digestion, mood, motor control, immune function, reproduction and fertility, pleasure and reward, memory, temperature regulation, and pain.

In cases where the endocannabinoid system is disrupted and gets out of whack because the body fails to produce enough endocannabinoids, disease and disorders can develop. In these cases, supplementing with plant cannabinoids (CBD) may be beneficial.

Did you know we all have an ENDOCANNABINOID SYSTEM in our body, and it's purpose is to keep us healthy?

Probably not...I now I didn't! I didn't hear it from my doctor, government, tv or even in health class at school. No mention of it in fact I didn't even know what CBD was until I was introduced to it over a year ago, and started my research into it.

Certainly by now we know not to believe everything you read on the internet or listen to those that have been ill informed, because of what they have "been told" by a controled curriculum (school) that they paid for.

During my research I found several Doctors talking about the Endocannabinoid System, and even found interviews done with the one doctor that named the system.

All of these doctors say how improtant it is to help your Endocannabinoid System by taking a small amount of CBD a day to signal your body to make more cannabinoids for your system to function at is potential.

Now whom would you believe here? The one that has been ill informed, because they were acting on the opinions of those that didn't have a clue what they were talking about? Or the multitude doctors I found during research?

My vote falls with the doctors and my research. Why? The doctors whom speak the truth did not learn it in their 8+ years of education. They only have one hour of class about nutrition, so why would they learn anything else about how to prevent sickness?

Doctors who start to think and research for themselves are the doctors we need to listen to.

When you listen to doctors who decide to not go with what their 8+ expensive years of education taught them, you hear how they get ridicule...but their results of going back to holostic medicine is so amazing.

These doctors are rewarded with healthy living patients that most of them were told by other "conventional" doctors that they are going to die from their illness.

Lucky for us, doctors whom think for themselves also love to share their discovery, giving those lives they touch a new beginning.

Here's a challenge for you, Google or even better YouTube search Endocannabinoid System or doctors such as...

  • Dr. Mechoulam along with Dr. William DeVane and Dr Lumir Hanus who named the system after years of research.
  • Dr. Dustin Sulak, an easy one to understand.
  • Dr Allan Frankel whom saw tumors disappear in front of his very eyes by only giving 40 to 60mg's of CBD to his patients.
  • Dr. Robert Melamede says how cannabis is an essential nutrient to lower the damage caused by a degree of unnecessary inflammatory responses.

Here are More Doctors for Your Search...

  • Dr David Allen
  • Dr Michael Smith
  • Dr Christopher Rasmussen
  • Dr Mercola
  • Christiane Northrup M.D. are just a few out of many more that freely spea the truth to help you cure and prevent illness. 

Why do I want you to now about your Endocannabinoid System? Simple! Your Endocannabinoid System balances the health in your cells creating homeostasis. Guess what? Your entire body is made up with these cells. When you're sick, it's because of unhealthy cells.

In a book titled "The Cannabis Index" by Uwe Blesching PhD that shows over 1,000 studies of how cannabis is the most POWERFUL plant on earth. If you want to discover more, this may be a great place to start.

I get that the endocannabinoid system is complex, which makes it easy to be scared away and just avoid the subject, but it is worth talking about. The more we talk about the endocannabinoid system and its components, the more legitimacy we add to cannabinoid research, and the more stigma is taken away.

"The Most Important Physiologic System Involved in Establishing and Maintaining Human Health."

As humans beings we're not special for having an ECS.

Not only is the endocannabinoid system found in all vertebrates, scientists also discovered cannabinoid receptors in non-vertebrate sea-squirts, suggesting an evolutionary process dating back 600 million years ago.

CB1 receptors are the most abundant neurotransmitter receptors in the brain

Most of us have heard of neurotransmitters - they're the chemicals that communicate information throughout the brain and body. Serotonin and dopamine are perhaps the most well known examples, but it's the endocannabinoid Anandamide, also classed as a neurotransmitter, that has the most receptors in the brain.

Endocannabinoids signal backwards

Most neurotransmitters communicate in one direction: from the signaling neuron to the postsynoptic neuron.

But in the endocannabinoid system, it works in the opposite direction, which is called retrograde signaling. This means that if a receptor is being over- or under-stimulated, it signals backwards across the synapse telling the signaling neuron to change its behavior, creating a kind of feedback loop.

So in effect, rather than distributing information like other neurotransmitters, it acts like a kind of dimmer switch, turning activity up or down in order to return the body to homeostasis.


Increased endocannabinoid system activity has been noted in many diseases

As the endocannabinoid system's modus operandi is to bring balance to the body, it's no surprise then that scientists have observed elevated ECS activity in a number of illnesses.

Everything from neurodegenerative diseases such as Alzheimer's and Parkinson's, to rheumatoid arthritis and cancer have shown changes in endocannabinoid levels and greater receptor expression.

The conclusion that has been most widely reached is that this increased activity denotes the ECS trying to fulfill its role of returning the body to homeostasis again.

"Endocannabinoid System Deficiency" may be a cause of some illnesses

But what happens if the ECS becomes depleted?

Scientists have observed how in certain conditions associated with oversensitivity to pain such as migraines, fibromyalgia and IBS, the ECS appears to have become weakened.

The theory is known as Clinical Endocannabinoid Deficiency, with the corollary being that by supplementing the body with compounds from the cannabis plant, this deficiency can be corrected and the symptoms improved.


The ECS explains why medicinal cannabis has a therapeutic effect

Prior to 20th century prohibition, cannabis had been used for thousands of years to treat a whole host of ailments from epilepsy, headaches, arthritis, pain, depression and nausea.

Back then nobody knew why the plant showed such therapeutic versatility. The discovery of the endocannabinoid system soon shone new light onto the medicinal effects of cannabis.

Sadly, this has coincided with a time when the vast majority of the population have been precluded from accessing it.

According to Dr. Dustin Sulak, a leading medical cannabis expert:

"Research has shown that small doses of cannabinoids from cannabis can signal the body to make more endocannabinoids and build more cannabinoid receptors…I believe that small, regular doses of cannabis might act as a tonic to our most central physiologic healing system."

Most doctors know very little about the endocannabinoid system

With the ECS playing such a central role in our health, you would think that any self respecting member of the medical profession would have some knowledge of its existence.

But in mainstream medicine, the endocannabinoid system remains rather a pariah. In 2013 a survey was conducted asking a medical school in the United States whether the ECS formed part of their curriculum.

It was found that only, "13% teach the endocannabinoid system to future doctors."

A lot can change in a few years, and while in some European countries such as the UK and Spain the ECS does make it onto some medical school syllabuses, it cannot be denied that the majority of professionals in charge of our healthcare remain very much in the dark.

So now that you are endocannabinoid savvy, there's no turning back.

Join me and start spreading the word to all that will listen. It's time that the ECS is given the attention it deserves both by our healthcare providers and the public at large.

If like me you feel moved to take action,

  • Why not start by speaking to your doctor?

  • Have they heard of the endocannabinoid system?

You never know, perhaps you are the very person to inform them.





These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. CTFO assumes no responsibility for the improper use of and self-diagnosis and/or treatment using these products. Our products should not be confused with prescription medicine and they should not be used as a substitute for medically supervised therapy. If you suspect you suffer from clinical deficiencies, consult a licensed, qualified medical doctor. You must be at least 18 years old to visit our website and make product purchases. We do not make any health claims about our products at CTFO. Before taking our products, it’s wise to check with your physician or medical doctor. It is especially important for people who are: pregnant, chronically ill, elderly, under 18, taking prescription or over the counter medicines. None of the information on our website is intended to be an enticement to purchase and may not be construed as medical advice or instruction. The use of any of our products for any reason, other than to increase general health and wellness, is neither, implied nor advocated by CTFO. 

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