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Gene Hughes (MD)
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Gene Hughes (MD)   My Press Releases

Bioavailability of CBD and Why It Matters

Published on 2/16/2019
For additional information  Click Here


The Bioavailability of CBD is a widely discussed subject these days within the CBD space. There are plenty of factors that decide on the final quality of Cannabidiol products, from the source of the hemp to the extraction methods to the quality systems in place in manufacturing and third-party lab testing. But in the end, what matters is how much of the CBD your body will absorb.

That being said, there’s no wonder that the bioavailability of CBD is on people’s minds these days. Once you figure out what the bioavailability of CBD is all about, you will finally get the answer to your burning question,  “How do we get the most effectiveness out of our CBD?”

 [Buy CBD Online

Bioavailability of CBD - What Is It?

As you may have noticed, CBD comes in many various forms. The list includes...

  • Concentrates
  • Tinctures
  • Oils
  • Lotions
  • Balms
  • e-Liquids
  • Capsules
  • Pet Treats

Each of these products requires a different usage approach. Moreover, each full-spectrum product typically has its own unique concentration of CBD and other cannabinoids.

If you have never used CBD or are not familiar with the industry, choosing between all these options can be quite overwhelming to say the least. I definitely understand your confusion and hesitance; you just want to try CBD, but which form will provide you with the best effects? How much CBD should you take? Am I right?

Addressing these questions with answers about what the bioavailability of CBD actually means will help you understand how to proceed.

Bioavailability is measured by the degree and rate at which a substance is absorbed into the bloodstream. 

By it's very definition, when a substance or supplement is administered intravenously, its bioavailability is 100%. However, when the same product is administered via other routes (such as orally), its bioavailability generally decreases, or may vary from patient to patient.

Bioavailability is one of the essential tools in pharmacokinetics, as bioavailability must be considered when calculating serving size for non-intravenous routes of administration.

Bioavailability is the third-most important factor, right after the amount and strength of a substance when it comes to getting the most out of your CBD oil. Bioavailability also helps calculate users their CBD dosage at the start.

The bioavailability of CBD can vary based on the concentration of CBD in the given product and the administration method, which brings us to another essential question...

What’s the Most Effective Way to Take CBD?

If you’re looking for the most effective way to administer CBD, this of course would be intravenously. 

In other words, CBD would be injected directly into the bloodstream through your veins.

This method ensures a 100% bioavailability of CBD, but it’s by far the least popular option. Now, if you don’t prefer to stick yourself with a needle, worry not. There are plenty of different methods of using CBD.

Let’s take a look and see how each affects the bioavailability of CBD.

Oral Consumption

This ingestion method doesn’t need an introduction. By oral consumption we mean consuming something through your mouth. When it comes to CBD, common oral consumption methods include CBD edibles, beverages, gummies, and capsules.

As much as we enjoy the benefits of eating CBD, the truth is that any substance consumed orally will have to pass through your digestive and metabolic systems, this harsh environment will in turn drastically reduce the bioavailability of CBD by filtering out a large portion of the cannabinoids.

According to a study conducted in 1986, the bioavailability rate of orally consumed products is 6%. Though, another study done in 2009 reported this rate to be between 4% and 20%. 

While these two results differ significantly, both indicate that the bioavailability of oral CBD products is not at all impressive, with 20% being the most optimistic between the two scenario.

How to Increase the Bioavailability of Oral CBD?

The well-described disadvantage of oral CBD consumption gives raise to an obvious question - can the bioavailability of CBD oil be increased when you take it orally?

Yes, and the solution is initially actually straightforward. Recent studies have proved the theory that cannabinoids consumed along with vegetable oils have higher availability than if used alone. As a matter of fact, the presence of vegetable oil can increase the bioavailability of CBD almost threefold.

How does it happen? CBD Oil has a very high affinity to chylomicrons, which are particles responsible for transporting the lipids from the small intestine to the bloodstream through the lymphatic system. This allows cannabinoids to bypass the liver, and as a result, you deliver more CBD to the bloodstream.

In a nut-shell, the more fats or oil you consume together with your daily intake of cannabinoids, the larger the lymph flow will be, and the more compounds will be able to get into the lymphatic system in their unmetabolized form.

Sublingual Consumption

Technically, this is a form of oral consumption, but with one major difference. When you use CBD orally, you apply them under the tongue. This is where a vein called the sublingual gland is located.

When you put a few drops of CBD oil to the sublingual gland, the substance will get absorbed directly into the bloodstream. Aside from oral tinctures, you can also utilize your sublingual glands by ingesting CBD lozenges and CBD sprays as well.

There are a couple of different factors that can affect the bioavailability of CBD for sublingual use, but the main factor is hands down the quality of CBD. Reported bioavailability rates range from 12% to 25%, which is still more effective than traditional oral consumption.

 Small 10xPure

In addition, an Exclusive and patented - brand-new product being brought to the market by the firm I represent shows Ground-Breaking results.

Our 10xPure product is hydrophilic, which means that it is attracted to water. A full spectrum product, it is estimated that bioavailability of the product is in the ninety percentile bracket!!!

Ground-Breaking 10X PURE CBD/CBDA

(The Verified Tests/Clinical studies are in: 8-10 times more bio-available than regular CBD!) Welcome to the new frontier of CBD/CBDA health technology...

Our Delivery System of 10xPure - The System brings the power of intravenous like therapy into a convenient oral delivery. Our 10xPure improves upon bioavailability technology with the most stable, highest-grade ingredients available.

In addition to exceptional absorption rates, produced by 10xPure has proven to have the ability to cross the blood-brain barrier, deposit their cargo intracellularly and enhance lymphatic circulation of nutrients. Also, this ensures the proper function for the absorption of nutrients and the excretion of cellular waste products and toxins.

What is 10xPure CBD Oil? 

The 10xPure process is of vital importance, because it strips away a lipid level (thin skin around the molecule) allowing it to become genuinely water soluble. 

Your bloods largest component is Plasma (water) therefore the CBD's can stay in the blood much longer and target dysfunctional cells and once again saturate your Cannabinoid receptors.

Basically, 10xPure is a revolutionary way to deliver broad spectrum CBD molecules/oil to your body by using 10x's supercharged oxygenated oil.

10xPure CBD oils is an IV infusion-like absorption using an exclusive and patented technology, which is taken sublingually or under your tongue.

It’s proved to be more absorbable than the pharmaceutical grade CBD oils, and yes even more powerful than nano liposomal technology.



  • Our 500mg potency with 10xPure is approximately equivalent to taking a dose of 3,000 mg – 5,000 mg!
  • Our 1500mg potency is approximately equivalent to taking a dose of 9,000 mg – 15,000 mg!



Vaporization is the new trend for both recreational and medical users who like to use dry herbs, and essential oils to improve the quality of their lives or solve different health concerns.

Vaporization involves inhaling CBD right into the lungs, using a special device called a vaporizer or vape pen. Because the inhaled cannabinoids directly enter the lungs, the CBD can reach the bloodstream within seconds. This method ensures lower breakdown rates and the higher bioavailability of CBD.

Moreover, vaporization is by far the most efficient method of CBD consumption with the exception of our 10xPure product. As numerous medical studies report, bioavailability rates of vaporized CBD are between 34% and 46%. Some studies even report up to 56% bioavailability.

If you’re looking for one of the safest and more effective methods of CBD delivery, you now have a choice between our 10xPure or vaping.


Other Factors Affecting the Bioavailability of CBD

All of the above methods are affected by the hydrophobic character of CBD oil. Typical CBD oil is not meant to dissolve in water (our 10x Pure product is the exception), and for that reason, it diffuses out of the bloodstream and gets stored in fatty tissues. This, in turn, cuts the concentration of active CBD in the endocannabinoid system. As a result, the oil is less bioavailable.

Still, there are two other factors that can affect the bioavailability of CBD, so let’s take a quick peek at them.

The Serving Size

The effects of CBD depends on the serving size, and the optimal serving may vary from person to person, and bioavailability of the product.

When trying CBD oil for the first time, start with the serving size that is lower than that recommended by your CBD company. If you don’t feel the desired effects after a week, or they are just too mild for you, increase the serving size for another week. Continue until you are satisfied with your results.

Here's a BIG One...The Quality of CBD Oil

Last but certainly not least, the CBD content depends on the quality of the CBD oil. Top-notch CBD products will be consistent and provide the exact level of CBD that is advertised on a company’s labels and website.

Make sure you always buy CBD oil from a reputable source that is open about the third-party lab testing results and sources its CBD from the finest, organic industrial hemp. GMP practices in manufacturing is another requirement that you should stand firm on!

This way, you will minimize the risk of falling into the trap of false promises made by some manufacturers in the industry.





These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. CTFO assumes no responsibility for the improper use of and self-diagnosis and/or treatment using these products. Our products should not be confused with prescription medicine and they should not be used as a substitute for medically supervised therapy. If you suspect you suffer from clinical deficiencies, consult a licensed, qualified medical doctor. You must be at least 18 years old to visit our website and make product purchases. We do not make any health claims about our products at CTFO. Before taking our products, it’s wise to check with your physician or medical doctor. It is especially important for people who are: pregnant, chronically ill, elderly, under 18, taking prescription or over the counter medicines. None of the information on our website is intended to be an enticement to purchase and may not be construed as medical advice or instruction. The use of any of our products for any reason, other than to increase general health and wellness, is neither, implied nor advocated by CTFO.

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