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Gene Hughes (MD)
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Gene Hughes (MD)   My Press Releases

Ask for CBDa Instead of CBD?!

Published on 6/7/2019
For additional information  Click Here


In recent years, there has been a lot of focus on the medical potential of CBD (cannabidiol), a non-intoxicating cannabinoid that has gentle sedative properties. CBD would not exist, however, without CBDA.

So...What Exactly Is CBDA?

CBDA is a cannabinoid... These are the compounds that serve as hemp’s active ingredients, and there are dozens of them within the plant. When introduced into the human brain and body, cannabinoids mimic the chemicals our brains naturally produce by plugging into the same receptors.

This means that cannabinoids can create a wide range of effects such as causing euphoria, alleviating pain, helping with depression, easing nausea, and more. In their activated state, these cannabinoids are known as THC, CBD, CBG, and so on. Before CBD and other cannabinoids are pharmacologically active, they exist in their acidic forms.

This means that the precursor to CBD in hemp is CBDA, or cannabidiolic acid. This is also the case with other cannabinoids, meaning that raw cannabis flower contains THCA, CBGA, CBCA, in addition to CBDA.

CBDA is a potent anti-inflammatory, working by selectively inhibiting an enzyme in our bodies called COX-2. This enzyme is triggered when you experience injury or infection, and it produces compounds called prostaglandins.

Prostaglandins promote inflammation, and although this is a natural response, it can be the source of significant pain and at times, cell destruction. CBDA reduces the production of prostaglandin by blocking the COX-2 enzyme.  Less prostaglandin equals less inflammation.  There is also a COX-1 enzyme, which when triggered, activates blood clotting and protection of the lining of the gut.

Scientists have long sought compounds that block COX-2 without blocking COX-1 -- and CBDA does just that.

Non-steroidal anti-inflammatory medications (NSAIDs) work by blocking both COX enzymes -- this is why they can cause side effects of bleeding, gut irritation, and ulcers. One particular NSAID, called celecoxib, is also a selective COX-2 inhibitor but has a long list of possible side effects including...

  • Headaches
  • Abdominal Pain
  • Indigestion
  • Nausea
  • Diarrhea
  • Dizziness
  • Insomnia
  • and More

There are No reports of these side effects with CBDA use. THCA, tetrahydrocannabinolic acid, the precursor to THC, also inhibits COX-2 but is much less potent than CBDA.

A fascinating experiment wherein volunteers ingested unheated cannabinoids (THCA and CBDA) along with heated cannabinoids (THC and CBD) found that ingesting unheated cannabinoids along with heated cannabinoids resulted in higher CBD plasma levels when compared to heated cannabinoids alone. It is theorized that unheated cannabinoids may beneficially affect the uptake and metabolism of CBD and other phytocannabinoids.

Another study showed that CBDA inhibited highly invasive breast cancer cells (called MDA-MB-231 cells) from metastasizing.

These cells are unresponsive to hormonal treatment and considered very difficult to treat. The researchers discovered that CBDA turned off the chemical signals that these particular cancer cells send to each other telling them to spread. Although this study was conducted in test tubes, not in animals or humans, it is quite promising and demands further investigation.

Research also shows that CBDA is sporostatic (stops mold spores from reproducing) and antibacterial, although these properties have not been studied in humans.

These plant cannabinoids have been nothing less than a

“Neglected Pharmacological Treasure Trove.”

We desperately need more research on these compounds, and with the promising results seen so far, CBDA is at the top of CTFO's research list.

Many common illnesses, including diabetes, schizophrenia, Alzheimer’s disease, cancer, and others, are thought to be a result of chronic inflammation.  CBDA just may be Mother Nature’s cure for all that ails us.

With the amount of emphasis that is placed on CBD, it may be surprising to learn that the raw hemp plant contains very little CBD. 

Instead, it contains an abundance of CBDa (the ratio is about 95% CBDa to 5% CBD at the highest.)

Oftentimes, it is a combination of cannabinoids that suit our bodies best. During what is known as the entourage effect, compounds such as cannabinoids and terpenes work with one another to produce an effect greater than the compound alone. It is suggested that taking CBD and CBDa together may provide more benefit than taking the compounds alone.      






These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. CTFO assumes no responsibility for the improper use of and self-diagnosis and/or treatment using these products. Our products should not be confused with prescription medicine and they should not be used as a substitute for medically supervised therapy. If you suspect you suffer from clinical deficiencies, consult a licensed, qualified medical doctor. You must be at least 18 years old to visit our website and make product purchases. We do not make any health claims about our products at CTFO. Before taking our products, it’s wise to check with your physician or medical doctor. It is especially important for people who are: pregnant, chronically ill, elderly, under 18, taking prescription or over the counter medicines. None of the information on our website is intended to be an enticement to purchase and may not be construed as medical advice or instruction. The use of any of our products for any reason, other than to increase general health and wellness, is neither, implied nor advocated by CTFO.

IMPORTANT NOTE: Almost all drug tests are designed to test for the presence of any Terpenes and/or Cannabinoids present in Marijuana (or Hemp.) They are NOT specifically testing for THC. This means that even with a true ZERO THC product like some of our products are, you can still test positive for a drug test. This is why we cannot guarantee any negative test results for people who are taking our products.

The information contained here is for general information and educational purposes only. It does not constitute medical advice. Therefore, any reliance you place on such information is strictly at your own risk. Please check with your medical doctor before starting or changing your CBD routine.


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