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Gene Hughes (MD)
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Gene Hughes (MD)   My Press Releases

Pros and Cons of CBD oil...

Published on 6/11/2019
For additional information  Click Here


There is no question that CBD oil has become the new sweetheart of alternative medicine...

Shops offering a plethora of CBD oil and oil-based products have sprung up everywhere from local gas stations to shopping malls, and even major drugstore chains such as CVS and Walgreens have begun stocking CBD-based “creams, sprays, roll-ons, lotions and salves” in parts of the country, according to a March 29 article in the USA Today.

But should this popularity be tempered with any precautions? Do CBD users need to be concerned about interactions with prescription medicines, or the results of mandatory drug testing for employment?

Popular – for a reason...

Certainly people are thinking about using CBD oil for a variety of "isms" or "itis's" treat a variety of inflammation-based conditions such as psoriasis, eczema, hives, irritable bowl syndrome and arthritis, and neurological conditions ranging from anxiety and muscle cramps to fibromyalgia and neuropathy. CBD oil has even proven effective for treating pain such as migraines and menstrual cramps. 

How can one thing have an effect on so many conditions? The answer to this is simple. Because the oil has a direct effect on your Endocannabinoid System (ECS) of the body.

The recently discovered endocannabinoid system “is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation!

Your endocannabinoid system is an ancient lipid signaling network which in mammals modulates neuronal functions, inflammatory processes, and is involved in the etiology of certain human lifestyle diseases, such as Crohn’s disease, atherosclerosis and osteoarthritis, and “the system is able to downregulate stress-related signals that lead to chronic inflammation and certain types of pain. (

Scientists have been researching the properties of the endocannabinod system since the 1990's, but because it is “attached to a plant with a huge amount of cultural resistance,” learning how it regulates conditions in the body has been slow.

So, Is it for you?

Individuals considering using CBD oil for a health condition should do some research first. The best way to locate reliable information is to go to your Internet browser and “type in CBD and your ailment.” This approach, will bring you to scholarly articles on the use of CBD oil to treat your condition “and cut through all the websites not giving scholarly information on CBD oil and actual illnesses.

During my research over the last several years I have found that Any drug metabolized by CYP450 enzymes could potentially interact with cannabidiol or CBD.

According to the Indiana University Department of Medicine, drugs known to use the CYP450 system include...

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDs
  • Angiotension II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

This list does not include all of the potential medications impacted by cannabidiol. Nor will every medication in the categories contained on this list will cause an interaction. For these reasons, you should consult with a medical professional before supplementing with CBD.

There are certain medications, known as “prodrugs,” that need to be metabolized to produce the therapeutic compound. In other words, you ingest an inactive compound and once in the body, it is processed into the active drug. If this processing is dependent on CYP3A4 (part of the larger CYP450 system), then inhibitors can result in too little active drug in the body for the desired therapeutic effect.

  • Codeine, for example, is a prodrug that is metabolized into morphine which provides the effect.
  • Vyvanse and Concerta are two other popular pharmaceutical medications for ADHD that fall into this category.

If you are worried that your CYP450 pathway may not be functioning properly, physicians can test the system to ensure that the medications you take are metabolizing as expected.

Go right to the National Institutes of Health or the British College of Pharmacy, do not read an article in the New York Times that is going to reference a study and the science is going to get lost in translation.

If you do choose to try CBD oil to address a health concern, it is important to inform you medical practitioners so they can monitor any interactions with prescription medicines and their dosing.

CBD oil effects the enzymes that can metabolize pharmaceuticals, Though most interactions are minimal, CBD could speed up the metabolization of some drugs - which means there is less in your system during the dosing period - or slow it down - which means there would be more drug in your system.

The upside of CBD oil use is that there is a potential for a patient to reduce the amount of drugs they are taking that are harmful. Prescription drugs serve an important use, but there are doses that are fatal. If you can work with a practitioner or expert [in CBD] to effectively manage your symptoms, you can reduce the amount of medicines you need.

As most doctors and specialists have access to the Internet in their offices, your health practitioner should be able to research any interactions and adjust your dosing. But, you the patient also needs to bring up any concerns or symptoms. Though you are working with a health practitioner, you are engaged in the process of keeping yourself healthy and well.

Those looking to use CBD oil should be aware that there are two types -whole plant and isolate. Whole plant, is the “full-spectrum CBD with all the plant’s natural oils including trace amounts of THC which is the psychoactive chemical in marijuana. Though, not enough to cause a psychoactive effect.

For individuals interested in learning more about CBD and its medicinal implications, the American Cannabis Nurses Association has a listing of books about the subject under the Resources tab on their website.

If you are looking for the absolute Best CBD Products on the Planet, you have found them...and we have the proof to back it up! 


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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. CTFO assumes no responsibility for the improper use of and self-diagnosis and/or treatment using these products. Our products should not be confused with prescription medicine and they should not be used as a substitute for medically supervised therapy. If you suspect you suffer from clinical deficiencies, consult a licensed, qualified medical doctor. You must be at least 18 years old to visit our website and make product purchases. We do not make any health claims about our products at CTFO. Before taking our products, it’s wise to check with your physician or medical doctor. It is especially important for people who are: pregnant, chronically ill, elderly, under 18, taking prescription or over the counter medicines. None of the information on our website is intended to be an enticement to purchase and may not be construed as medical advice or instruction. The use of any of our products for any reason, other than to increase general health and wellness, is neither, implied nor advocated by CTFO.

IMPORTANT NOTE: Almost all drug tests are designed to test for the presence of any Terpenes and/or Cannabinoids present in Marijuana (or Hemp.) They are NOT specifically testing for THC. This means that even with a true ZERO THC product like some of our products are, you can still test positive for a drug test. This is why we cannot guarantee any negative test results for people who are taking our products.

The information contained here is for general information and educational purposes only. It does not constitute medical advice. Therefore, any reliance you place on such information is strictly at your own risk. Please check with your medical doctor before starting or changing your CBD routine.


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